Effect of surface treatments of titanium on amphotericin B-treated Candida albicans persister cells.

Patients with long-term oral carriage harbor high-persister mutants of Candida albicans.

Fungal biofilms produce a small number of persister cells which can tolerate high concentrations of fungicidal agents. Persisters form upon attachment to a surface, an important step in the pathogenesis of Candida strains. The periodic application of antimicrobial agents may select for strains with increased levels of persister cells. In order to test this possibility, 150 isolates of Candida a...

Inhibition of nucleic acid biosynthesis makes little difference to formation of amphotericin B-tolerant persisters in Candida albicans biofilm.

Candida albicans persisters constitute a small subpopulation of biofilm cells and play a major role in recalcitrant chronic candidiasis; however, the mechanism underlying persister formation remains unclear. Persisters are often described as dormant, multidrug-tolerant, nongrowing cells. Persister cells are difficult to isolate and study not only due to their low levels in C. albicans biofilms ...

Inhibitory Effect of Fluconazole Combined with Amphotericin B on Fluconazole-Resistant Candida albicans Biofilm Formation

 Background & Objective:  The incidence of biofilm-related infections caused by Candida albicans has increased dramatically. C. albicans biofilm-related infections are more resistant to antifungal medications. This work was an attempt to examine inhibitory effects of fluconazole in combination with amphotericin B on fluconazole-resistant C. albicans biofilm.  Materials & Methods:  Fluconazole-...

Inhibition of nucleic acids biosynthesis makes little difference to amphotericin 1 B - tolerant persister formation in Candida albicans biofilm

Fungal Biofilms

• They are responsible for a broad spectrum of microbial infections in the human host [1] • Candida albicans and Candida parapsilosis biofilms are relatively resistant to fluconazole, amphotericin B, nystatin, voriconazole and others [2]. • Aspergillus fumigatus biofilms are relatively resistant to itraconazole and, to some extent, to caspofungin [3]. • Cryptococcal biofilms are unaffected by f...